Arnošt Hübsch was born on 22 November 1905 in Lukavec in the Pelhřimov District. His parents were Kamila and Karel Hübsch. He was a shop owner and married to Anna née Khámová. The couple had a daughter named, Irena. His last residence before deportation was in Ondřejov, then in Prague XII, Schwerinova 15. On 5 June 1942, he was deported to Theresienstadt concentration camp by transport AAb. His transport number was 218 of 745. After seven days there, on 12 June 1942, he was deported to Trawniki concentration camp by transport AAk. His transport number was 422 of 1,027. He was murdered by the Nazi regime on 8 August 1942 in Majdanek.

The fate of his wife is unknown. His only daughter survived, studied, achieved a doctorate in natural sciences, married and took the name Kimlová. In 1991, she submitted the report on his death to Yad Vashem.